Effects of Menopausal Hormone Therapy on Liver Function and Non-Alcoholic Fatty Liver Disease: A Prospective Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This prospective study aims to evaluate the effects of menopausal hormone therapy (MHT) on liver function, lipid profiles, and hepatic steatosis in postmenopausal women. A total of 44 participants will be divided into two groups: 22 received MHT and 22 were monitored without treatment. Biochemical parameters, FIB-4 scores, and attenuation imaging (ATI) measurements are assessed at baseline and after six months. The study investigates whether MHT is associated with favorable changes in liver enzymes, hepatic fat accumulation, and noninvasive fibrosis markers.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 40
Healthy Volunteers: f
View:

• Female participants aged 40 years or older

• Postmenopausal status (defined as ≥12 months of amenorrhea)

• No prior use of menopausal hormone therapy in the last 6 months

• Willingness to participate and provide informed consent

Locations
Other Locations
Turkey
Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine
RECRUITING
Istanbul
Time Frame
Start Date: 2024-10-30
Estimated Completion Date: 2025-12
Participants
Target number of participants: 44
Treatments
Active_comparator: Group 1: MHT Group
Postmenopausal women receiving menopausal hormone therapy (oral or transdermal estrogen). Evaluated at baseline and after 6 months for liver function, lipid profile, FIB-4 score, and attenuation imaging.
No_intervention: Group 2: Control Group
Postmenopausal women not receiving MHT. Monitored without treatment and evaluated using the same laboratory and imaging parameters.
Sponsors
Leads: Ipek B. Ozcivit Erkan, MD

This content was sourced from clinicaltrials.gov